With Rei now dead, only three of the Six Sacred Fists of Nanto remain and Kenshiro sets off to find the remaining ones. One of them, a man named Souther, has proclaimed himself to the "Holy Emperor" and seeks to conquer the world as well.

Kenshiro meets a blind martial artist rebelling against Souther named Shu, who is also one of the Six Sacred Fists.

While saving a group of children slaves from Souther's troops, Ken remembers that he once fought Shu in the past, back when he was still a child.